cardiovascular medicine papers

Cardiovascular medicine focuses on the heart and blood vessels, exploring how to prevent, diagnose, and treat conditions that affect our circulation. This vital field ranges from understanding high blood pressure and heart failure to investigating the latest breakthroughs in surgical techniques and lifestyle interventions. Because these discoveries directly impact public health, staying informed about emerging research is more important than ever for both specialists and curious readers.

At Gist.Science, we process every new preprint in this category as it appears on medRxiv, ensuring you have immediate access to the latest findings before they undergo formal peer review. For each study, we provide both a plain-language explanation to clarify the core concepts and a detailed technical summary for those seeking deeper scientific context. Below are the latest papers in cardiovascular medicine, organized to help you navigate the most recent developments shaping the future of heart health.

📄 cardiovascular medicine

Factors Associated with Adherence to Anti-Hypertensive Medication Among Patients Attending a Primary Health Centre in Ndola, Zambia: A Cross-Sectional Study

This cross-sectional study of 237 hypertensive patients in Ndola, Zambia, reveals a suboptimal medication adherence rate of 41.4% driven by a complex interplay of socio-demographic factors, clinical challenges like side effects and comorbidities, and significant health system barriers including drug stock-outs and transport difficulties.

Sikantongwe, N., Musonda, E., Mabaso, F., Chibwaya, E., Sikantongwe, E., Mapiki, C.2026-09-17

📄 cardiovascular medicine

Automated Identification of Complex Percutaneous Coronary Intervention from Cardiac Catheterization Reports Using Large Language Models

This study demonstrates that high-capacity open-source large language models, particularly Llama 3.3 70B, can accurately and automatically identify complex percutaneous coronary intervention procedures and extract key variables from free-text cardiac catheterization reports, offering a scalable alternative to labor-intensive manual abstraction for cardiovascular research.

Bhatt, N., Warner, F., Miao, J., Thakker, R., Joodi, G., Cantero-Schaffer, P., Huang, C., Krumholz, H., Murugiah, K.2026-09-16

📄 cardiovascular medicine

A self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (the DIGICHOL randomised controlled trial)

In a pragmatic randomized controlled trial, the self-guided digital health application lipodia significantly reduced LDL-cholesterol levels and improved patient activation and quality of life compared to usual care alone in adults with hypercholesterolaemia, demonstrating a scalable solution for delivering guideline-mandated lifestyle support.

Riepenhausen, A., Ekerdt, C., Meyer, B., Jauch-Chara, K.2026-09-16

📄 cardiovascular medicine

A Comparative Analysis of Signal Quality and Morphological Fidelity in ECG Smartwatches

This study objectively compares the signal quality and morphological fidelity of four leading smartwatches against a Philips reference standard, revealing that the Apple Watch and Withings ScanWatch offer superior signal-to-noise ratios, the Withings device provides the most stable baseline, and the Apple Watch delivers the most balanced ST-segment classification performance.

Muhammed, S. M., Omran, N. A., Sowelam, S.2026-09-10

📄 cardiovascular medicine

Genetically predicted expression of cuproptosis and copper-transport genes and coronary artery disease risk: a cis-Mendelian randomization and colocalization study

This study utilizes cis-Mendelian randomization and colocalization analyses to demonstrate that while cuproptosis and copper-transport genes are upregulated in atherosclerotic plaques, their genetically predicted baseline expression does not causally influence coronary artery disease risk, suggesting their plaque presence is a consequence rather than a driver of the disease.

Guan, W., Wanqi, L., Meizhuo, G., Yue, X.2026-09-08

📄 cardiovascular medicine

Ejection fraction on a budget: mapping the accuracy-compute trade space for video-based ejection fraction estimation

This paper systematically maps the accuracy-compute trade-off for video-based ejection fraction estimation by evaluating 22 model configurations, revealing that sparse temporal sampling with specific backbones like R3D-18 or R(2+1)D-18 can significantly reduce computational costs while maintaining expert-level accuracy, thereby providing clear deployment guidance for resource-constrained clinical tools.

Pandey, A., Sharma, K., Shah, A.2026-09-07

📄 cardiovascular medicine

Reconstructing synthetic hearts from ECG using flow matching

This paper introduces visionECG, a conditional flow matching framework that leverages large-scale UK Biobank data to reconstruct accurate, patient-specific 3D left ventricular geometries and motion directly from widely accessible ECG signals and demographic information, thereby enabling scalable quantitative cardiac assessment without the need for traditional imaging.

Zheng, J., Kalaie, S., Ma, Q., Meng, Q., Rjoob, K., Gifani, P., Hu, L., Babazade, N., Coriano, M., Zhong, W., Vafaeezade (…)2026-09-04

📄 cardiovascular medicine

Dose-finding, experimental medicine evaluation of sodium valproate for the prevention of post-cardiac surgery myocardial injury

This experimental medicine trial demonstrates that short-term preoperative administration of sodium valproate (15 mg/kg/day for ≤14 days) is well-tolerated and reduces post-cardiac surgery myocardial injury by activating ferroptosis protection pathways, whereas longer treatment durations induce adverse heart failure phenotypes and increased injury.

Roman, M., Beasley, N., Ladak, S. S., Solomon, C. U., Liao, W., Lai, F., Joel-David, L., Aujla, H., Condorelli, G., Wozn (…)2026-09-02

📄 cardiovascular medicine

Soft-Tissue versus Hematologic Primary Malignant Cardiac Tumors: Demographics and First-Course Treatment Patterns in the SEER Registry

This study analyzing SEER registry data from 2000 to 2021 reveals that soft-tissue and hematologic primary malignant cardiac tumors exhibit distinct demographic profiles, histological compositions, and first-course treatment patterns, with soft-tissue cases more frequently undergoing surgery and hematologic cases more often receiving chemotherapy, though the latter showed higher unadjusted survival rates among those treated with chemotherapy.

Mathew, Z., Mehta, R., Kim, S., Jeyaraj, J., Asif, T.2026-08-31

📄 cardiovascular medicine

CHARMS and PROBAST+AI: an updated template for Data Extraction and Risk of Bias Assessment in systematic reviews of prediction models

This paper presents an updated, open-access Excel template that integrates the CHARMS checklist with the new PROBAST+AI framework to provide a standardized, automated tool for data extraction and risk of bias assessment in systematic reviews of both traditional and AI-driven clinical prediction models.

Jaber, A., Hughes, L., Cameron, A. C., Quinn, T. J.2026-08-31